San Francisco -1.5 after Kyler Murray expected to be out. The two teams met in a 17-10 win for the Cardinals in October. Garoppolo was out for that one, in 4 games he has gone for 8.5 YPA, 316 YPG, 11 TD and 2 INT with a 115.9 Rating. Of course Kittle is still out for SF. In the Murray era SF is 3-2 vs. Arizona. Jimmy G is 3-1 in his 4 games facing the Cardinals.
Murray and Hopkins most likely out for this one. They were averaging 35.8 ppg on the road. Things for Arizona change as the injury report does. They only face two teams the rest of the way with winning records.
My prediction 20-13 49ers.