Buffalo won big last week and they come in a huge -17 favorite here, 47 the total, -1500 ML, +870 Texans ML. This one has the Texans in an uphill battle. Davis Mills does have the highest QB rating among rookie QBs(80.9). Texans are +3 in turnovers, scoring 22 per game, giving up 25 and 385.7 YPG. That may be the best way to look at things for this team because any other look at things you would have them in a blowout loss.
The Bills have won 8 of 9 regular season games by more than 10, 78-21 in their last two games. 31.3 ppg, while allowing 14.7 and 252.7 YPG(4th rank defense). As far as outright win there is no stat that makes me think the Bills have a chance of losing this game.
However I don’t recommend laying the -17, that is a huge number right there. I would find another game to put money on if thats what your after because this game will unless something unspeakable happens will go however the Bills decide it goes. Historically when the line gets that big I would just lay off the game because the Texans are in that Davis vs. Goliath role here. My prediction 32-19 Bills.